Lady Penelope was a weekly comic for girls publiched by City Magazines, later IPC, and launched on 22 January 1966 as a sister publication to TV Century 21, edited by Gillian Allan until 1968, then by Chris Spencer. From issue 53 to 62 it was known as The New Lady Penelope, and from issue 123 to 204 it was called simply Penelope. It ended with issue 204, dated 13 December 1969, after which it was merged into Princess Tina.
Lady Penelope, the character from Thunderbirds, had first appeared as a strip in TV Century 21, written by Alan Fennell and Scott Goodall and drawn by Eric Eden and John Cooper, before the TV series had even been shown, and led the new title, written by Alan Fennell and drawn mainly by Frank Langford, and sometimes by Michael Strand and John M. Burns. Other strips, mostly based on TV series, included:
- "The Angels" - spin-off from Captain Scarlet and the Mysterons
- "The Monkees"
- "The Beverly Hillbillies"
- "Class Six Sterndorf" - about a special class where young girls are trained to become spies, created by Angus Allan
- "Creighton Ward" - stories about a young nurse, Pat, on a children's hospital ward
- "The Man From U.N.C.L.E." (Gonzalez, Ron Embleton)
- "The Girl From U.N.C.L.E."
- "Jenny Ware" - humorous stories about a girl who accidentally discovers a chemical that sends her backward or forward in time
- "Marina, Girl of the Sea" - spin-off of Stingray
- "Penny" - stories about Lady Penelope when she was a young girl
- "Perils of Parker" - humorous stories based loosely on the character from Thunderbirds
- "Space Family Robinson" (Jim Baikie)
- "What Did That Dog Say?" - humorous stories about a girl who can understand the language of dogs thanks to a magic ring, created by Angus Allan as a text story, later a comic strip